Benoquin, sometimes
referred to as Monobenzone can be
described to be a monobenzyl ether belonging to hydroquinone. It mainly occurs
as a crystalline powder that is almost tasteless. It is white in color and it
dissolves in alcohols, though it does not dissolve in water. Chemically, this
component has been designated as a p-(benzyloxy) phenol; with an empirical formula
as C13H12O2. Its molecules weigh 200.24mg in every gram of its cream.
Applying monobenzone topically to animals may increases the rate at which melanin is excreted from the animals’ melanocytes. This same action has been held responsible for depigmentation effect of these drugs to human beings. The drug is likely to destruct the melanocytes and as well permanently cause depigmentation. The effect is normally erratic, and it may take up to four months before it occurs. The melanin that exists will also be lost due to normal sloughing in the stratum corneum. The skin that has been hyper pigmented appears to be fading very rapidly as compared to normal skin. However, exposing one to direct sunlight will reduce that depigmenting effect caused by that drug. A patient of this condition usually has a normal epidermis except that the epidermis lacks identifiable melanocytes.
In Vitiligo, Benoquin cream has been indicated for being responsible for the final pigmentation process. When applies, it permanently depigments normal skin especially for patients who possess disseminated idiopathic vitiligo (vitiligo refers to the condition that causes the skin to lose its color). This cream has never been recommended for hyperpigmentation that has resulted from photosensitization brought about by application of certain perfumes, pregnancy melasma or those resulting from skin inflammation. This drug has also not been recommended for treating café-au-lait spots, nevi pigments, malignant melanoma and neither has it been recommended to treat pigmentations that are caused by other pigments that are not melanin. Some of these other pigments are, bile, artificial pigments and silver.
This drug also contains some potential depigmenting agent which is not considered as a cosmetic skin bleaching agent. The use of anything containing this drug, take for example Benoquin Cream 20% has been contraindicated in any other conditions apart from disseminated vitiligo. It has also been burned from being used in place of hydroquinone. This has been attributed to the fact that the use of it leads to depigmentation that is irreversible. The terms and conditions controlling the use of this drug explains that he drug should not be used by individuals who are allergic and sensitive to the drug, or to any of the ingredients in that drug.
As part of the cautions which come enclosed with this drug, it has been made clear that the drug is not just a mild bleaching agent but it is a highly potential depigmenting agent. It should never be used at all, unless it is being used for the ultimate depigmentation in the extensive vitiligo. This drug, like any other should be kept out of reach of children. In case a person accidentally ingests it, they should contact a qualified physician with immediate effect.
Applying monobenzone topically to animals may increases the rate at which melanin is excreted from the animals’ melanocytes. This same action has been held responsible for depigmentation effect of these drugs to human beings. The drug is likely to destruct the melanocytes and as well permanently cause depigmentation. The effect is normally erratic, and it may take up to four months before it occurs. The melanin that exists will also be lost due to normal sloughing in the stratum corneum. The skin that has been hyper pigmented appears to be fading very rapidly as compared to normal skin. However, exposing one to direct sunlight will reduce that depigmenting effect caused by that drug. A patient of this condition usually has a normal epidermis except that the epidermis lacks identifiable melanocytes.
In Vitiligo, Benoquin cream has been indicated for being responsible for the final pigmentation process. When applies, it permanently depigments normal skin especially for patients who possess disseminated idiopathic vitiligo (vitiligo refers to the condition that causes the skin to lose its color). This cream has never been recommended for hyperpigmentation that has resulted from photosensitization brought about by application of certain perfumes, pregnancy melasma or those resulting from skin inflammation. This drug has also not been recommended for treating café-au-lait spots, nevi pigments, malignant melanoma and neither has it been recommended to treat pigmentations that are caused by other pigments that are not melanin. Some of these other pigments are, bile, artificial pigments and silver.
This drug also contains some potential depigmenting agent which is not considered as a cosmetic skin bleaching agent. The use of anything containing this drug, take for example Benoquin Cream 20% has been contraindicated in any other conditions apart from disseminated vitiligo. It has also been burned from being used in place of hydroquinone. This has been attributed to the fact that the use of it leads to depigmentation that is irreversible. The terms and conditions controlling the use of this drug explains that he drug should not be used by individuals who are allergic and sensitive to the drug, or to any of the ingredients in that drug.
As part of the cautions which come enclosed with this drug, it has been made clear that the drug is not just a mild bleaching agent but it is a highly potential depigmenting agent. It should never be used at all, unless it is being used for the ultimate depigmentation in the extensive vitiligo. This drug, like any other should be kept out of reach of children. In case a person accidentally ingests it, they should contact a qualified physician with immediate effect.